STAG1

Overview

STAG1 (Stromal Antigen 1) is a component of the cohesin complex and a paralog of STAG2. It interacts with CTCF to regulate chromatin insulation. In Ewing sarcoma genomics, STAG1 is discussed mechanistically as the paralog of the recurrently mutated STAG2 tumor suppressor.

Alterations observed in the corpus

• STAG1 discussed mechanistically in Ewing sarcoma WGS study as the paralog of STAG2 in the cohesin complex; STAG2 interacts with CTCF to regulate chromatin insulation at loci including CDKN2A PMID:25223734

Cancer types (linked)

• ES (Ewing sarcoma) — discussed in context of cohesin complex biology; STAG2 (the paralog) is the recurrently mutated subunit PMID:25223734

Co-occurrence and mutual exclusivity

• STAG1 is a functional paralog of STAG2; in Ewing sarcoma, STAG2 loss predominates; STAG1-specific mutations are not reported in this cohort PMID:25223734

Therapeutic relevance

Open questions

• Whether STAG1 mutations contribute to Ewing sarcoma or other cancers independently of STAG2 loss is unresolved PMID:25223734

Sources

• PMID:25223734

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