STAT4

Overview

STAT4 (Signal Transducer and Activator of Transcription 4) is a transcription factor in the JAK-STAT signaling pathway, important for immune response regulation. A GWAS susceptibility locus at STAT4 has been associated with HBV- or HCV-related hepatocellular carcinoma risk.

Alterations observed in the corpus

• STAT4 is a GWAS susceptibility locus/SNP associated with HBV- or HCV-related HCC risk PMID:24735922

Cancer types (linked)

• Hepatocellular carcinoma (HCC): germline susceptibility locus in viral hepatitis-related HCC PMID:24735922

Co-occurrence and mutual exclusivity

Therapeutic relevance

Open questions

Sources

• PMID:24735922

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