STING1
Overview
STING1 (Stimulator of Interferon Genes) is the downstream effector of the cGAS-STING innate immune sensing pathway, activated by cytosolic DNA. In the corpus, cGAS-STING pathway activation is observed as early as the STIC precursor stage of high-grade serous ovarian carcinoma (HGSOC), driven by ruptured micronuclei.
Alterations observed in the corpus
- cGAS-STING pathway is activated in HGSOC precursor lesions: cGAS is recruited to BANF1+ micronuclei as early as the STIC.I stage; STING1 contributes to innate immune signaling from ruptured micronuclei through STICs and into invasive HGSOC PMID:39386723.
Cancer types (linked)
- HGSOC — cGAS-STING activation detected in fallopian tube precursor lesions (p53 signatures, STICs) and concurrent HGSOC by multimodal spatial profiling PMID:39386723.
Co-occurrence and mutual exclusivity
- cGAS-STING activation co-occurs with STAT1-driven IFN signaling, HLA-E upregulation, and IFN-stimulated gene (ISG) induction progressively from p53 signatures through STIC.C to invasive HGSOC PMID:39386723.
Therapeutic relevance
- Chronic cGAS-STING/IFN signaling may contribute to the IRDS (IFN-related DNA Damage Resistance Signature) and chemoresistance in HGSOC; STING agonists or pathway modulation represent potential early interception strategies in high-risk patients PMID:39386723.
Open questions
- Whether STING1 expression levels in precursor lesions predict progression to invasive HGSOC, and whether cGAS-STING pathway activation is a driver or passenger of malignant transformation, is not resolved in the corpus PMID:39386723.
Sources
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