STK19
Overview
STK19 is a predicted serine/threonine kinase with a well-characterized D89N hotspot mutation found in ~4–5% of cutaneous melanomas; it was identified as a novel significantly mutated gene in melanoma. It appears as a putative SCC-associated gene discussed but not assayed in a metastatic cutaneous SCC NGS study, and is listed among genes with identical COSMIC-reported mutations in the HNSCC TCGA cohort.
Alterations observed in the corpus
- Discussed as a putative SCC-associated gene but not assayed in the targeted panel used for the cSCC cohort (n=29) PMID:25589618
- Listed among additional SCC-associated genes (with ASCL4 and FOXP1) discussed outside the assay panel in the cSCC NGS study PMID:25589618
Cancer types (linked)
- cSCC: Putative SCC-associated gene, noted in literature but not assayed in the cohort PMID:25589618
Co-occurrence and mutual exclusivity
Therapeutic relevance
Open questions
- Functional role in cSCC is not established in this cohort; listed as a gene of interest from prior melanoma work PMID:25589618
Sources
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