SYNE2

Overview

SYNE2 (Spectrin Repeat Containing Nuclear Envelope Protein 2) encodes a large nuclear envelope scaffolding protein related to SYNE1. Somatic mutations in SYNE2 have been identified in head and neck squamous cell carcinoma (HNSCC) by whole-exome sequencing.

Alterations observed in the corpus

  • Somatic mutations in SYNE2 detected by whole-exome sequencing of 74 HNSCC tumor-normal pairs (Broad cohort) PMID:21798893
  • Mutations in 9.2% (6/65) of triple-negative breast cancers in WGS cohort PMID:22495314

Cancer types (linked)

  • HNSC: SYNE2 identified as a somatically mutated gene in HNSCC whole-exome sequencing PMID:21798893

Co-occurrence and mutual exclusivity

Therapeutic relevance

  • No direct therapeutic implications established in the corpus.

Open questions

  • Whether SYNE2 somatic mutations are drivers or passengers in HNSCC requires functional validation; SYNE1 and SYNE2 may be co-selected due to their shared nuclear envelope function.

Sources

This page was processed by entity-page-writer on 2026-05-06. - PMID:22495314

This page was processed by wiki-cli on 2026-05-06.