SYP

Overview

SYP (Synaptophysin) encodes an integral membrane glycoprotein of small presynaptic vesicles and a well-established marker of neuroendocrine differentiation. In cancer genomics it serves as a diagnostic marker for neuroendocrine tumours, including small cell lung cancer (SCLC), where its expression level defines one of two major transcriptional subtypes.

Alterations observed in the corpus

• Expressed as a defining neuroendocrine marker in SCLC transcriptional subtype 2 (the minority subgroup, ~23% of RNA-seq cases, n=16/69); contrasts with subtype 1 which is characterised by high ASCL1/CHGA/GRP/DLK1 PMID:26168399

Cancer types (linked)

• SCLC: SYP expression marks the minority transcriptional subtype in unsupervised RNA-seq clustering of 69 SCLC tumours; major driver mutations (TP53, RB1, CREBBP) do not differ between subtypes PMID:26168399

Co-occurrence and mutual exclusivity

Therapeutic relevance

Open questions

Sources

• PMID:26168399

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