TACC1

Overview

TACC1 (Transforming Acidic Coiled-Coil Containing Protein 1) encodes a centrosome-associated protein that interacts with Aurora A kinase and plays a role in mitotic spindle assembly and chromosomal stability. The TACC domain near the C-terminus mediates protein-protein interactions and is a hotspot for cancer-associated mutations. TACC family members have been implicated in chromosomal instability and mitotic dysregulation in cancer. TACC1 was identified as a candidate driver in melanoma through whole-exome sequencing.

Alterations observed in the corpus

  • Distributed missense mutations near the C-terminus and TACC domain identified in ~7% of melanoma WES cohort (121 tumors, Broad); TACC1 interacts with Aurora A kinase; functional validation was not performed in this study PMID:22817889
  • Mentioned as a background-context gene in the pilocytic astrocytoma WGS study: FGFR1:TACC1 fusions (analogous to the more common FGFR3:TACC3 fusions in adult glioblastoma) are noted as conceptual parallels for the FGFR1 kinase-domain activations discovered in pediatric low-grade glioma PMID:23817572

Cancer types (linked)

  • SKCM: Candidate significantly mutated gene in cutaneous melanoma at ~7% prevalence; mutation clustering near the TACC domain suggests functional relevance PMID:22817889

Co-occurrence and mutual exclusivity

  • No co-occurrence or mutual exclusivity data reported in the corpus.

Therapeutic relevance

  • Aurora A kinase interaction suggests potential indirect relevance to Aurora kinase inhibitor biology, though no direct therapeutic targeting data are available PMID:22817889

Open questions

  • Functional validation of TACC1 mutations in melanoma oncogenesis is pending; role as an Aurora A interactor requires experimental dissection in cancer context PMID:22817889

Sources

This page was processed by crosslinker on 2026-05-09. - PMID:23817572

This page was processed by crosslinker on 2026-05-09.