TAF1

Overview

TAF1 encodes the largest subunit of the TFIID general transcription factor complex, which nucleates RNA polymerase II assembly at core promoters. TAF1 has intrinsic kinase and acetyltransferase activities that regulate promoter recognition and transcription initiation. Somatic mutations in TAF1 are rare and have been reported across several cancer types.

Alterations observed in the corpus

  • Single-case splice-site mutation identified in sinonasal adenoid cystic carcinoma (AdCC) whole-exome/RNA-seq profiling; classified among rare single-case driver candidates PMID:24418857
  • Mutated in 9.5% of CCEC (8 missense mutations); recurrent HAT-domain residues Arg843 and Ala850; first report of somatic TAF1 mutation in CCEC and nominated as a candidate driver PMID:28485815

Cancer types (linked)

Co-occurrence and mutual exclusivity

  • Observed as isolated single-case event without reported co-mutation patterns PMID:24418857

Therapeutic relevance

  • No direct therapeutic targeting reported in this corpus.

Open questions

  • Functional significance of the TAF1 splice-site mutation in AdCC is uncharacterized.

Sources

This page was processed by entity-page-writer on 2026-05-09. - PMID:28485815

This page was processed by wiki-cli on 2026-05-15.