TAF15

Overview

TAF15 (TATA-Box Binding Protein Associated Factor 15) is a TET-family RNA-binding protein. In Ewing sarcoma, TAF15 serves as an alternative N-terminal fusion partner for EWSR1 in rare cases where the canonical EWSR1-FLI1/ERG fusions are absent.

Alterations observed in the corpus

  • TAF15 identified as an alternative TET-family N-terminal fusion partner with EWSR1 in rare Ewing sarcoma cases (alongside FUS); context is translocation variant tumors where the canonical EWSR1-ETS fusions are absent PMID:25223734

Cancer types (linked)

  • ES (Ewing sarcoma) — rare alternative EWSR1 fusion partner; the canonical EWSR1-FLI1 fusion accounts for ~90% of cases PMID:25223734

Co-occurrence and mutual exclusivity

Therapeutic relevance

Open questions

Sources

This page was processed by entity-page-writer on 2026-05-11.