TBC1D3
Overview
TBC1D3 encodes a RAB GTPase-activating protein (GAP) family member. It was identified through whole-exome sequencing of pancreatic cystic neoplasms as a recurrently altered gene in intraductal papillary mucinous neoplasms (IPMNs), contributing to the somatic mutational landscape of these precursor lesions.
Alterations observed in the corpus
- WES of 32 pancreatic cystic neoplasms (IPMNs, MCNs, SCAs, SPNs) identified TBC1D3 as a recurrently mutated gene in IPMNs, contributing to the catalog of somatic alterations in pancreatic cystic precursor lesions PMID:22158988
Cancer types (linked)
- PAAD (pancreatic adenocarcinoma precursor context): Mutations detected in IPMN cystic neoplasms, which are precursors to invasive pancreatic cancer PMID:22158988
Co-occurrence and mutual exclusivity
- No co-occurrence or mutual exclusivity data in the current corpus.
Therapeutic relevance
- No direct therapeutic relevance established in the current corpus.
Open questions
- Functional significance of TBC1D3 mutations in pancreatic cystic neoplasm progression is not established.
Sources
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