TCHH
Overview
TCHH (Trichohyalin) encodes a structural protein of the inner root sheath of hair follicles. In uveal melanoma, TCHH carries recurrent missense mutations, though without current functional support for a driver role; it is flagged as a candidate recurrent mutation in the context of a deep-sequencing study.
Alterations observed in the corpus
- 2 missense mutations identified in uveal melanoma (UM) WGS cohort (n=28); flagged as recurrent but without functional support for a driver role PMID:26683228
Cancer types (linked)
- UM: Recurrent missense mutations (2/28 samples) in uveal melanoma; candidate recurrent alteration without confirmed oncogenic function PMID:26683228
Co-occurrence and mutual exclusivity
Therapeutic relevance
Open questions
- Functional significance of TCHH mutations in uveal melanoma is unknown; the mutations may be passenger events.
Sources
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