TENT5C
Overview
TENT5C (formerly FAM46C) encodes a non-canonical poly(A) polymerase that promotes immunoglobulin mRNA stability in plasma cells. It is one of the most frequently mutated genes in multiple myeloma, acting as a tumor suppressor whose loss disrupts the post-transcriptional regulation essential for plasma cell differentiation. Mutations are rare in non-myeloma cancers, underscoring its tissue-specific role.
Alterations observed in the corpus
- Recurrently mutated in multiple myeloma (MM); collectively with DIS3, altered in approximately 21% of patients; noted as rare in non-MM cancers, highlighting plasma-cell-specific functional importance PMID:24434212
Cancer types (linked)
- MM: recurrent mutations (~21% collectively with DIS3) in a comprehensive MM genomic analysis; myeloma-enriched alteration pattern PMID:24434212
Co-occurrence and mutual exclusivity
- Frequently co-altered with DIS3 (exonuclease) in multiple myeloma, both functioning in post-transcriptional RNA regulation PMID:24434212
Therapeutic relevance
- No direct therapeutic targeting reported in this corpus; loss of TENT5C may sensitize cells to agents disrupting mRNA homeostasis.
Open questions
- Mechanisms by which TENT5C loss promotes myelomagenesis beyond disruption of immunoglobulin mRNA stability are under investigation.
Sources
This page was processed by crosslinker on 2026-05-09.