TET3

Overview

TET3 (Tet Methylcytosine Dioxygenase 3) is a DNA demethylation enzyme that converts 5-methylcytosine to 5-hydroxymethylcytosine. Somatic mutations with recurrent hotspots in TET3 were identified in colorectal cancer, representing one of the first reports of TET family mutations in CRC.

Alterations observed in the corpus

Somatic mutations with recurrent hotspots in colorectal cancer; among the first reports of TET family somatic mutations in CRC PMID:22895193

Cancer types (linked)

COAD: somatic mutations with recurrent hotspots (Genentech WES cohort, 74 CRC tumors) PMID:22895193

Co-occurrence and mutual exclusivity

Therapeutic relevance

Open questions

Sources

PMID:22895193

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