THSD7B
Overview
THSD7B (Thrombospondin Type 1 Domain Containing 7B) encodes a protein with thrombospondin-type 1 repeat domains involved in angiogenesis regulation. In cancer genomics, it was identified as a novel somatically mutated gene in prostate cancer, not previously reported in this context.
Alterations observed in the corpus
- Novel somatically mutated gene identified in prostate cancer WES (112 tumors); not previously known to be somatically altered in prostate cancer PMID:22610119
Cancer types (linked)
- Prostate cancer: novel somatic mutations identified in WES cohort of 112 tumors PMID:22610119
Co-occurrence and mutual exclusivity
- No co-occurrence or mutual exclusivity data reported in the corpus.
Therapeutic relevance
- No direct therapeutic associations reported in the corpus.
Open questions
- Driver vs. passenger status of THSD7B mutations in prostate cancer is unresolved.
Sources
This page was processed by entity-page-writer on 2026-05-06.