TLN2
Overview
TLN2 (Talin 2) encodes a cytoskeletal protein involved in integrin-mediated cell adhesion, actin filament assembly, and cell migration. It is a paralogue of Talin 1 (TLN1). In cancer genomics, TLN2 has been identified as a recurrently mutated gene in adenoid cystic carcinoma of the breast (breast AdCC), representing one of only two genes with recurrent mutations in this low-mutation-burden tumour type.
Alterations observed in the corpus
- Missense mutations in 2 of 12 breast AdCC tumours (17%; cases AdCC2T and AdCC12T) identified by WES; represents one of only two recurrently mutated genes in this cohort (alongside MYB); involved in actin filament assembly and cell migration PMID:26095796
Cancer types (linked)
- ACBC: recurrent missense mutations in 17% (2/12) of breast AdCC; recurrence is notable given the overall low somatic mutation burden (0.27 non-silent mutations/Mb) of this tumour type PMID:26095796
Co-occurrence and mutual exclusivity
Therapeutic relevance
Open questions
- Whether TLN2 missense mutations are drivers or passengers in breast AdCC has not been functionally determined; the small cohort size (n=12) limits statistical power PMID:26095796
Sources
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