TMEM87B

Overview

TMEM87B is a transmembrane protein-coding gene identified as the 5’ fusion partner for MERTK in pan-cancer fusion analyses. Its biological function is not well characterized. TMEM87B-MERTK fusions represent recurrent singleton-pattern kinase fusions identified in the TCGA pan-cancer RNA-seq fusion landscape study.

Alterations observed in the corpus

• Identified as a 5’ fusion partner of MERTK in the TCGA pan-cancer RNA-seq fusion landscape; TMEM87B-MERTK constitutes a recurrent singleton-pattern kinase fusion PMID:29617662

Cancer types (linked)

Co-occurrence and mutual exclusivity

Therapeutic relevance

Open questions

• Whether TMEM87B-MERTK fusions are druggable and which cancer types they occur in is not yet characterized in the corpus PMID:29617662

Sources

• PMID:29617662

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