TNFRSF14
Overview
TNFRSF14 (TNF Receptor Superfamily Member 14), also known as HVEM (Herpesvirus Entry Mediator), encodes a receptor involved in immune co-stimulation and co-inhibition. In lymphomas, TNFRSF14 functions as a tumor suppressor with recurrent nonsense mutations identified in GCB-subtype diffuse large B-cell lymphoma and follicular lymphoma, suggesting a role in immune evasion.
Alterations observed in the corpus
- Recurrently mutated (nonsense) in diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL); acts as a tumor suppressor in GCB-restricted pattern identified by whole-genome/exome sequencing PMID:21796119
- WES of 55 DLBCL tumors identified recurrent TNFRSF14 mutations, implicating disruption of B-cell immune checkpoint signaling in diffuse large B-cell lymphoma PMID:22343534
- Preferentially mutated in GCB DLBCL PMID:28985567
Cancer types (linked)
- Diffuse large B-cell lymphoma (DLBCL): inactivating nonsense mutations; GCB-restricted pattern PMID:21796119
- Follicular lymphoma (FL): inactivating nonsense mutations PMID:21796119
Co-occurrence and mutual exclusivity
- GCB-restricted mutation pattern, likely co-occurring with EZH2, KMT2D, and other GCB-enriched alterations PMID:21796119
Therapeutic relevance
- Loss of TNFRSF14 may impair immune surveillance, with implications for immunotherapy response; potential biomarker for checkpoint inhibitor efficacy in DLBCL PMID:21796119
Open questions
- The mechanism by which TNFRSF14 loss promotes lymphomagenesis versus enabling immune evasion in GCB lymphomas is not yet fully defined.
Sources
This page was processed by entity-page-writer on 2026-05-06. - PMID:22343534
This page was processed by wiki-cli on 2026-05-06. - PMID:28985567
This page was processed by wiki-cli on 2026-05-15.