TRIM24

Overview

TRIM24 (TIF1A) is a transcriptional co-regulator with bromodomain and PHD finger domains. In the corpus, TRIM24 is identified as a 5’ fusion partner for BRAF in the tumor-agnostic BRAF fusion landscape.

Alterations observed in the corpus

  • TRIM24 was identified as a 5’ fusion partner for BRAF among 82 unique partners across 52 histologies in a tumor-agnostic BRAF fusion cohort (MSK-IMPACT/MSK-Fusion) PMID:38922339.
  • TRIM24–NTRK2 fusion identified in a lung ADC sample in a 1,144-NSCLC exome-sequencing cohort PMID:27158780.

Cancer types (linked)

  • Not specifically linked to a single cancer type in the corpus; BRAF fusions involving TRIM24 were observed across diverse histologies PMID:38922339.

Co-occurrence and mutual exclusivity

  • TRIM24-BRAF fusions co-occur with TP53 mutations (22% across all histologies) and other frequent co-alterations in BRAF fusion-positive tumors PMID:38922339.

Therapeutic relevance

Open questions

  • Clinical characteristics and response rates specific to TRIM24-BRAF fusions are not separately reported in the corpus PMID:38922339.

Sources

This page was processed by crosslinker on 2026-05-04. - PMID:27158780

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