TRPC4AP
Overview
TRPC4AP encodes transient receptor potential cation channel subfamily C member 4-associated protein, which interacts with MYCN and has been implicated in ubiquitin-mediated protein regulation. Its role in cancer is not well established, but recurrent expressed mutations in rhabdomyosarcoma suggest it may be a candidate driver in pediatric sarcomas.
Alterations observed in the corpus
- Recurrently expressed mutations (2 cases) in a comprehensive rhabdomyosarcoma (RMS) genomic analysis; interacts with MYCN; flagged as a candidate target requiring functional validation PMID:24436047
Cancer types (linked)
- RMS: recurrent expressed mutations in pediatric RMS genomic characterization PMID:24436047
Co-occurrence and mutual exclusivity
- Co-listed with ZNF350 as a recurrently expressed mutation candidate in RMS PMID:24436047
Therapeutic relevance
- MYCN interaction raises potential relevance to MYCN-driven oncogenesis in RMS; no direct therapeutic targeting reported in this corpus.
Open questions
- Whether TRPC4AP mutations are drivers or passengers in RMS requires functional validation.
Sources
This page was processed by crosslinker on 2026-05-09.