TTC28
Overview
TTC28 (Tetratricopeptide repeat domain 28) is located on chromosome 22 and has no well-characterised function in normal cellular biology. In cancer genomics, TTC28 has been identified as a site of clustered chromosomal breakpoints in small cell lung cancer (SCLC), suggesting it may be subject to recurrent inactivating translocations in this tumour type.
Alterations observed in the corpus
- Clustered chromosomal breakpoints at the TTC28 locus on chromosome 22 detected by whole-genome sequencing of 110 SCLC tumours, producing inactivating translocations PMID:26168399
- Source of recurrent somatic L1 retrotransposition in 28.2% of WGS cholangiocarcinoma tumors PMID:28667006
Cancer types (linked)
- SCLC: recurrent clustered breakpoints identified by WGS; biological significance undefined PMID:26168399
Co-occurrence and mutual exclusivity
Therapeutic relevance
Open questions
- The functional consequence of TTC28 inactivation in SCLC is unknown; no functional experiments were reported PMID:26168399
Sources
This page was processed by entity-page-writer on 2026-05-14. - PMID:28667006
This page was processed by wiki-cli on 2026-05-15.