UBE2QL1

Overview

UBE2QL1 (ubiquitin-conjugating enzyme E2 Q-like 1) is a ubiquitin-conjugating enzyme family member. In cancer genomics it has been identified as a structural-variant partner of ADCY2 in acral lentiginous melanoma, the most rearranged gene in that disease subtype.

Alterations observed in the corpus

• UBE2QL1 identified as a structural-variant partner of ADCY2 — the most frequently rearranged gene (21% of patients) in a 34-patient acral lentiginous melanoma (ACRM) whole-genome sequencing cohort; all ADCY2 rearrangements (including the UBE2QL1 partnership) occurred in BRAF wild-type tumors PMID:28373299.

Cancer types (linked)

• ACRM (acral lentiginous melanoma): structural-variant partner of ADCY2 in a subset of patients PMID:28373299.

Co-occurrence and mutual exclusivity

• ADCY2-UBE2QL1 rearrangements occur in BRAF wild-type ALM; relationship to NRAS/NF1 status not specified PMID:28373299.

Therapeutic relevance

• No direct therapeutic relevance established from the corpus.

Open questions

• Whether UBE2QL1 contributes functionally to the oncogenic activity driven by ADCY2 rearrangements, or is a passive partner, has not been determined PMID:28373299.

Sources

• PMID:28373299

This page was processed by crosslinker on 2026-05-14.