USP10

Overview

USP10 (Ubiquitin Specific Peptidase 10) is a deubiquitinase that regulates p53 stability and other cellular processes. In pancreatic ductal adenocarcinoma, it was identified as a MutSigCV-significant novel gene, though its functional role in PDA biology remains to be validated.

Alterations observed in the corpus

• Identified as a MutSigCV-significant recurrently mutated gene in pancreatic ductal adenocarcinoma (109-case WES cohort); oncogenic vs. passenger status awaits orthogonal functional validation. PMID:25855536
• Deubiquitinase that stabilizes TRMT10A; co-overexpressed with TRMT10A in mCRPC tissue; ~10% deep deletions in SU2C/PCF mCRPC cohorts; druggable with spautin-1, which combined with olaparib shows synthetic-lethal synergy (HSA synergy >10 in cell lines, CI=0.76 in 22Rv1 CDX) in BRCA1/2-WT mCRPC PMID:28068672

Cancer types (linked)

• PAAD: MutSigCV-significant mutation; functional role in PDA not established. PMID:25855536

Co-occurrence and mutual exclusivity

• No specific co-occurrence or mutual exclusivity patterns reported in the corpus.

Therapeutic relevance

• No therapeutic relevance established in the corpus.

Open questions

• Oncogenic vs. passenger status in PDA awaits orthogonal functional validation. PMID:25855536

Sources

• PMID:25855536
• PMID:28068672

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