USP22

Overview

USP22 (Ubiquitin Specific Peptidase 22) is a deubiquitinase and component of the SAGA histone acetyltransferase complex involved in transcriptional regulation. In lung cancer, USP22 has emerged as a novel amplification target identified by the TCGA Pan-Lung comprehensive genomic characterization study across 1,144 NSCLC cases.

Alterations observed in the corpus

  • Identified as a novel amplification target in lung adenocarcinoma (LUAD) or squamous cell carcinoma (LUSC) in the TCGA Pan-Lung comprehensive genomic characterization of 1,144 cases PMID:27158780.

Cancer types (linked)

Co-occurrence and mutual exclusivity

  • No specific co-occurrence or mutual exclusivity data reported in the current corpus.

Therapeutic relevance

  • No direct therapeutic targeting of USP22 established in the corpus; amplification in lung cancer is hypothesis-generating.

Open questions

  • The functional significance of USP22 amplification in NSCLC and whether it represents a driver or passenger event has not been determined.

Sources

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