WASF2

Overview

WASF2 (WAS protein family member 2, also known as WAVE2) encodes an actin nucleation-promoting factor that regulates the ARP2/3 complex. In the pan-cancer TCGA fusion landscape, WASF2 was identified as the 5’ partner in FGR-WASF2 fusions, where the WASF2 5’ UTR promoter drives FGR kinase overexpression in the majority of fusion-positive samples.

Alterations observed in the corpus

• Identified as the 5’ UTR-donor partner in FGR-WASF2 fusions across seven pan-cancer samples; the WASF2 5’ UTR promoter drives FGR overexpression in five of seven fusion-positive samples PMID:29617662

Cancer types (linked)

Co-occurrence and mutual exclusivity

Therapeutic relevance

Open questions

• The cancer-type distribution and therapeutic relevance of FGR-WASF2 fusions is not yet characterized in the corpus PMID:29617662

Sources

• PMID:29617662

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