WNT5B

Overview

WNT5B (Wnt family member 5B) encodes a non-canonical Wnt ligand involved in developmental signaling. In cholangiocarcinoma, WNT5B expression is upregulated in the Cluster 2 molecular subtype alongside CTNNB1 and AKT1, pointing to activated Wnt/PI3K signaling as a feature of this subtype.

Alterations observed in the corpus

• Upregulated expression in Cluster 2 cholangiocarcinoma (p < 0.05) alongside CTNNB1 and AKT1 PMID:28667006

Cancer types (linked)

• Cholangiocarcinoma: WNT5B upregulation is a defining feature of Cluster 2 (Fluke-positive-enriched) molecular subtype in the 489-sample multi-omic CCA cohort PMID:28667006

Co-occurrence and mutual exclusivity

• Co-upregulated with CTNNB1 and AKT1 in CCA Cluster 2; Cluster 2 tumors are significantly enriched for ERBB2 amplification PMID:28667006

Therapeutic relevance

• Wnt pathway activation (WNT5B/CTNNB1) in Cluster 2 is a candidate therapeutic vulnerability; no specific Wnt-targeted agent tested in this cohort PMID:28667006

Open questions

• Whether WNT5B upregulation is a driver or passenger in CCA Cluster 2 remains unresolved; functional validation studies are lacking PMID:28667006

Sources

• PMID:28667006

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