XRCC1

Overview

XRCC1 encodes X-ray repair cross-complementing protein 1, a scaffold protein essential for base excision repair (BER) and single-strand break repair. Low-penetrance XRCC1 variants are GWAS susceptibility loci for gastric cancer, contributing individually small but potentially cumulative risk increments in the context of familial non-hereditary gastric cancer.

Alterations observed in the corpus

• Low-penetrance XRCC1 variants (DNA-repair polymorphisms) identified as GWAS susceptibility loci for gastric adenocarcinoma; individually small risk effects but may contribute to familial aggregation in the context of H. pylori and shared environment. PMID:24816255

Cancer types (linked)

• STAD — XRCC1 DNA-repair polymorphisms are low-penetrance susceptibility loci in gastric cancer, listed alongside GSTM1-null and other xenobiotic-metabolism variants as potential contributors to familial non-hereditary gastric cancer (FNHGC). PMID:24816255

Co-occurrence and mutual exclusivity

• XRCC1 variants are co-listed with GSTM1-null as DNA-repair/xenobiotic-metabolism susceptibility loci in FNHGC. PMID:24816255

Therapeutic relevance

• No direct XRCC1-targeted therapy data for gastric cancer reported in the current corpus.

Open questions

• Polygenic risk scores integrating XRCC1 and other DNA-repair variants with H. pylori exposure and family history are not yet clinically actionable for FNHGC risk stratification. PMID:24816255

Sources

• PMID:24816255

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