YWHAZ
Overview
YWHAZ encodes 14-3-3 zeta/delta, a member of the 14-3-3 family of regulatory proteins that mediate signal transduction by binding phosphoserine-containing proteins. In the expanded TCGA bladder cancer analysis, YWHAZ was identified as a focal copy-number amplification target by GISTIC 2.0 analysis.
Alterations observed in the corpus
- YWHAZ is identified as a focal copy-number amplification target in the GISTIC 2.0 analysis of 412 chemotherapy-naive muscle-invasive bladder cancers (BLCA) in the expanded TCGA cohort PMID:28988769.
Cancer types (linked)
- BLCA — recurrent focal amplification identified among 34 amplified focal regions (q < 0.1) by GISTIC analysis in the 412-tumor expanded TCGA MIBC cohort PMID:28988769.
Co-occurrence and mutual exclusivity
- No co-occurrence or mutual exclusivity data specific to YWHAZ reported in the corpus.
Therapeutic relevance
- No direct targeted therapy for YWHAZ amplification is reported in the corpus.
Open questions
- The functional consequence of YWHAZ amplification in bladder cancer and whether it confers subtype-specific dependencies or therapeutic vulnerabilities has not been characterized in the corpus PMID:28988769.
Sources
This page was processed by crosslinker on 2026-05-15.