ZAP70
Overview
ZAP70 (Zeta-chain-associated protein kinase 70) encodes a tyrosine kinase critical for T-cell receptor signalling, but in B-cell malignancies — particularly chronic lymphocytic leukaemia (CLL) — ZAP70 is aberrantly expressed and serves as a well-established adverse prognostic biomarker. ZAP70 expression in CLL B cells correlates with unmutated IGHV status, ZAP70 positivity by flow cytometry, and aggressive clinical course.
Alterations observed in the corpus
- ZAP70 mRNA and protein upregulated in double-mutant (SF3B1-mut/del(13q)) CLL cells versus del(13q)-only CLL cells; used as a CLL-cell identity/activation marker alongside CD5 PMID:26200345
Cancer types (linked)
- CLLSLL: ZAP70 upregulation in SF3B1-mutant/del(13q) CLL confirms the more aggressive phenotype of the double-mutant subtype compared to Mdr-only (del(13q)-only) cells PMID:26200345
Co-occurrence and mutual exclusivity
- Elevated ZAP70 expression co-occurs with SF3B1 mutation and del(13q) in CLL, consistent with the known association between ZAP70 positivity and poor-prognosis CLL features PMID:26200345
Therapeutic relevance
Open questions
Sources
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