ZFP36L1

Overview

ZFP36L1 is a NOTCH1 negative regulator disrupted in U-CLL via a recurrent chr14 deletion.

Alterations observed in the corpus

  • ZFP36L1 is disrupted (together with DICER1 and TRAF3) by a recurrent 37-Mb chr14 deletion in U-CLL (4/87 WGS, 4.6%) arising via class-switch recombination PMID:35927489.
  • ZFP36L1 is a NOTCH1 negative regulator, and its loss connects the structural-variant landscape of U-CLL to NOTCH1 pathway activation PMID:35927489.
  • Significantly mutated gene (SMG) at frequency ≤8% in bladder urothelial carcinoma (BLCA) in the TCGA comprehensive genomic characterization PMID:24476821
  • Identified as a Mut-driver in breast cancer in the METABRIC/ICGC 2,433-sample targeted-panel WES; inactivating mutations associated with worse breast-cancer-specific survival in ER+ disease PMID:27161491.

Cancer types (linked)

  • CLLSLL — disrupted by the recurrent U-CLL chr14 deletion PMID:35927489.
  • BRCA (ER+): Mut-driver; inactivating mutations associated with worse breast-cancer-specific survival PMID:27161491.

Co-occurrence and mutual exclusivity

Therapeutic relevance

  • No direct targeted therapy reported in the corpus; mechanistically links to NOTCH1 pathway PMID:35927489.

Open questions

  • Relative contribution of ZFP36L1 loss vs co-disrupted DICER1/TRAF3 to U-CLL biology is unresolved PMID:35927489.

Sources

This page was processed by crosslinker on 2026-05-09. - PMID:24476821 - PMID:27161491

This page was processed by entity-page-writer on 2026-05-15.