ZIC1

Overview

ZIC1 (Zic family member 1) encodes a zinc-finger transcription factor involved in neural development. In medulloblastoma, ZIC1 is a recurrently altered candidate driver identified across multiple subgroups in large-scale genomic profiling.

Alterations observed in the corpus

• Recurrently altered candidate driver across medulloblastoma subgroups in the 491-sample ICGC cohort PMID:28726821

Cancer types (linked)

• Medulloblastoma: ZIC1 identified as a recurrent candidate driver across subgroups in the 491-sample somatic landscape analysis PMID:28726821

Co-occurrence and mutual exclusivity

• Appears in the oncoprint of recurrently altered candidate drivers across Group 3, Group 4, WNT, and SHH medulloblastoma subgroups PMID:28726821

Therapeutic relevance

• No direct therapeutic relevance reported; ZIC1 alterations are candidate drivers requiring further functional characterization PMID:28726821

Open questions

• Specific alteration class (mutation, deletion, amplification) and subgroup enrichment pattern for ZIC1 in medulloblastoma require further delineation from subgroup-level oncoprint data PMID:28726821

Sources

• PMID:28726821

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