ZIM2

Overview

ZIM2 (zinc finger imprinted 2) encodes a Kruppel-type zinc finger protein involved in genomic imprinting. It is located in the imprinted region on chromosome 19q13.4. ZIM2 was identified as a significantly mutated gene in pancreatic ductal adenocarcinoma, potentially linking imprinting dysregulation to PDAC pathogenesis.

Alterations observed in the corpus

  • Identified as a significantly mutated gene in pancreatic cancer WES of 142 ICGC tumors PMID:23103869

Cancer types (linked)

  • Pancreatic ductal adenocarcinoma (PAAD): significantly mutated; functional role in PDAC requires further characterization PMID:23103869

Co-occurrence and mutual exclusivity

  • No co-occurrence or mutual exclusivity patterns reported in the corpus.

Therapeutic relevance

  • No direct therapeutic relevance reported in the corpus.

Open questions

  • Whether ZIM2 mutations are drivers or passengers in PDAC, and their functional consequences for imprinting and gene regulation, require investigation PMID:23103869

Sources

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