ZMYND11
Overview
ZMYND11 (Zinc Finger MYND-Type Containing 11), also known as BS69, is a chromatin reader protein that recognizes H3.3K36me3 and functions as a transcriptional co-repressor. ZMYND11 has been identified as a novel significantly mutated gene (SMG) in non-small cell lung cancer by the TCGA Pan-Lung comprehensive genomic characterization study covering 1,144 cases.
Alterations observed in the corpus
- Identified as a novel significantly mutated gene (SMG) in lung cancer in the TCGA Pan-Lung comprehensive genomic characterization of 1,144 NSCLC cases PMID:27158780.
Cancer types (linked)
- LUAD / LUSC: ZMYND11 is a novel SMG in non-small cell lung cancer identified by the TCGA Pan-Lung study PMID:27158780.
Co-occurrence and mutual exclusivity
- No specific co-occurrence or mutual exclusivity data reported in the current corpus.
Therapeutic relevance
- No direct therapeutic targeting of ZMYND11 established in the corpus; loss of this chromatin reader may contribute to epigenetic dysregulation in NSCLC.
Open questions
- The precise mutation spectrum and subtype distribution (ADC vs SqCC) of ZMYND11 mutations in the Pan-Lung cohort, and their functional consequences for H3.3K36me3 reading, remain to be characterized.
Sources
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