ZNF217

Overview

ZNF217 encodes a zinc-finger transcription factor located on chromosome 20q13 that is recurrently focally amplified in the chromosomal instability (CIN) subtype of gastric cancer.

Alterations observed in the corpus

• Focal amplification in the CIN subtype of gastric cancer (TCGA); co-amplified alongside MYC, GATA4, GATA6, and CD44 at this locus. PMID:25079317
• Novel amplification target in lung adenocarcinoma (LUAD) identified in the TCGA Pan-Lung comprehensive genomic characterization of 1,144 NSCLC cases PMID:27158780.

Cancer types (linked)

• Gastric cancer / CIN subtype (STAD): ZNF217 is part of a cluster of recurrent focal amplifications characterizing the chromosomally instable gastric subtype. PMID:25079317
• LUAD: Novel amplification target identified in the TCGA Pan-Lung study PMID:27158780.

Co-occurrence and mutual exclusivity

• Co-amplified with MYC, GATA4, GATA6, and CD44 as part of the CIN focal amplification landscape in gastric cancer. PMID:25079317

Therapeutic relevance

• No direct therapeutic targeting of ZNF217 reported; amplification co-occurs with other potentially actionable CIN alterations (RTK amplifications, CDK amplifications).

Open questions

• The functional contribution of ZNF217 amplification to CIN gastric tumorigenesis, independent of co-amplified oncogenes such as MYC, has not been assessed in the citing study.

Sources

• PMID:25079317

• PMID:27158780

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