ZNF595

Overview

ZNF595 (Zinc Finger Protein 595) encodes a Kruppel-type zinc finger transcription factor. It was identified as a novel somatically mutated gene in prostate cancer, representing one of several previously unreported candidate drivers in this malignancy.

Alterations observed in the corpus

• Novel somatically mutated gene identified in prostate cancer WES (112 tumors); not previously known to be somatically altered in prostate cancer PMID:22610119

Cancer types (linked)

• Prostate cancer: novel somatic mutations identified in WES cohort of 112 tumors PMID:22610119

Co-occurrence and mutual exclusivity

• No co-occurrence or mutual exclusivity data reported in the corpus.

Therapeutic relevance

• No direct therapeutic associations reported in the corpus.

Open questions

• Driver vs. passenger status of ZNF595 mutations in prostate cancer is unresolved.

Sources

• PMID:22610119

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