ZNF703

Overview

ZNF703 (Zinc Finger Protein 703) encodes a transcriptional repressor in the Nlz (neural lazarillo) family. Located at 8p12, it is focally amplified in a subset of ER-positive breast cancers and has been identified as the likely driver of the 8p12 amplicon, acting as an oncogene that promotes luminal progenitor cell proliferation.

Alterations observed in the corpus

• Focal amplification in a subset of ER-positive breast cancers; identified as a candidate oncogene at 8p12 in METABRIC cohort (2,000 tumors) PMID:22522925
• ZNF703 identified as a significantly mutated gene in breast cancer WES of 100 tumors (Sanger cohort) PMID:22722201
• Focal amplification in 10% of bladder urothelial carcinomas (BLCA) in the TCGA comprehensive genomic characterization PMID:24476821
• Driver CNA at 8p11 defining IntClust6 in breast cancer; identified as a copy-number taxonomy anchor in the METABRIC/ICGC 2,433-sample study PMID:27161491.
• Identified as a focal amplification target by GISTIC 2.0 analysis of 412 muscle-invasive bladder cancers (BLCA) in the expanded TCGA cohort PMID:28988769.

Cancer types (linked)

• Breast cancer (ER-positive): focal amplification at 8p12 PMID:22522925
• BRCA: Driver CNA at 8p11 defining IntClust6 in the METABRIC/ICGC 2,433-sample breast cancer study PMID:27161491.

Co-occurrence and mutual exclusivity

• No co-occurrence or mutual exclusivity data reported in the corpus.

Therapeutic relevance

• No direct therapeutic associations reported in the corpus.

Open questions

• Functional mechanisms by which ZNF703 amplification drives ER-positive breast cancer proliferation warrant further characterization.

Sources

• PMID:22522925
• PMID:22722201
• PMID:24476821
• PMID:27161491
• PMID:28988769

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