ZNF765

Overview

ZNF765 (Zinc Finger Protein 765) is a KRAB-domain zinc finger protein. It was identified as significantly mutated in chromophobe renal cell carcinoma (chRCC) in a comprehensive non-clear cell RCC genomic study, though its functional role in cancer remains uncharacterized.

Alterations observed in the corpus

ZNF765 identified as significantly mutated in chromophobe renal cell carcinoma (chRCC) in a comprehensive UTSW nccRCC study; functional characterization in cancer is lacking PMID:25401301

Cancer types (linked)

CHRCC (chromophobe renal cell carcinoma) — significantly mutated; oncogenic vs passenger status unestablished PMID:25401301

Co-occurrence and mutual exclusivity

Therapeutic relevance

Open questions

ZNF765 lacks functional characterization in cancer; its oncogenic versus passenger status in chRCC is unestablished PMID:25401301

Sources

PMID:25401301

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