Cancer Imaging Phenomics Toolkit (CaPTk)
Overview
CaPTk (Cancer Imaging Phenomics Toolkit) is an open-source software platform developed at the Center for Biomedical Image Computing and Analytics (CBICA) at the University of Pennsylvania. It provides a graphical and command-line interface for neuroimaging analysis, including seed-point initialization for tumor segmentation, volumetric radiomic feature extraction, and pre-processing pipelines. CaPTk is tightly integrated with GLISTRboost and the BraTS challenge ecosystem. Its radiomic feature extraction module generates >700 features from tumor sub-region labels across intensity, volumetric, morphologic, histogram, textural (GLCM/GLRLM/GLSZM/NGTDM), and wavelet domains.
Used by
- PMID:28872634 — CaPTk used for seed-point initialization of the GLISTRboost segmentation pipeline and for volumetric radiomic feature extraction (>700 features) from the manually revised tumor sub-region labels of 243 pre-operative glioma MRI scans (TCGA-GBM n=135, TCGA-LGG n=108); radiomic features extracted from ET, NET, and ED regions in 3D PMID:28872634.
Notes
- CaPTk is available at https://www.cbica.upenn.edu/captk; it is actively developed and has expanded beyond glioma segmentation to include other brain tumor and multi-cancer applications since the Bakas et al. 2017 paper.
- The >700 radiomic features extracted by CaPTk in Bakas et al. are explicitly described as hypothesis-generating; their individual biological significance is not established PMID:28872634.
Sources
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