CBCT delta radiomics

Overview

CBCT (Cone-Beam CT) delta radiomics is an imaging-based method that extracts quantitative radiomic features from serial on-treatment cone-beam CT scans acquired during a radiation therapy course, then computes the delta (change) between time points. The approach enables high-temporal-resolution monitoring of treatment response without requiring additional dedicated imaging sessions, since CBCT is routinely acquired for patient positioning at each treatment fraction.

Used by

PMID:41941260 — CBCT delta radiomics is being standardized across ROBIN consortium institutions by the CBCT Working Group (CBCT WG), which harmonizes Cone-Beam CT acquisition protocols to enable cross-center integrative analysis; deployed within the METEOR center (Washington University, St. Louis) for on-treatment adaptive imaging in locally advanced cervical and pancreatic cancer patients on trial NCT05975593 PMID:41941260.

Notes

Corpus-grown slug; not present in canonical ontology.
The ROBIN CBCT WG explicitly flags the need for harmonized acquisition protocols and artifact correction before cross-center delta-radiomics analyses are robust.
Longitudinal CBCT data are archived as DICOM-RT plans; METEOR-CRATR (NCT05975593) had 126 DICOM-RT plans archived at time of writing.
Complements molecular biomarker assays (ctDNA, spatial transcriptomics) in the METEOR center’s multimodal treatment-response monitoring strategy.

Sources

PMID:41941260

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