NanoString CosMx SMI

Overview

NanoString CosMx Spatial Molecular Imager (SMI) is a high-plex in situ single-cell spatial profiling platform that measures RNA (and optionally protein) expression directly on formalin-fixed paraffin-embedded tissue sections, including tissue microarrays, at subcellular resolution PMID:39214094.

Used by

• PMID:39214094 — applied to a tissue microarray of 20 PAAD patients (14 tumors, 6 normal pancreas) to profile allele-specific transcriptional programs in KRAS-mutant PDAC, identifying enriched KRAS signaling and EMT in KRAS^G12D tumors versus increased TNF/NF-κB signaling in KRAS^G12R tumors PMID:39214094.

Notes

• High-plex in situ RNA profiling on FFPE / TMA sections; used here as the spatial complement to bulk RNA-seq on 100 tumors PMID:39214094.
• Corpus-grown slug; not present in canonical schema/ontology/gene_panels.json (CosMx is an imaging platform, not a targeted DNA panel), so marked unverified: true.

Sources

• PMID:39214094

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