EricScript

Overview

EricScript is a computational tool for discovering gene fusions in paired-end RNA-seq data. It uses a probabilistic model to identify chimeric transcripts from discordant and split read evidence. EricScript was used as one of three callers in the TCGA pan-cancer fusion analysis, complementing STAR-Fusion and BREAKFAST.

Used by

• One of three RNA-seq fusion callers in the TCGA pan-cancer fusion analysis across 9,624 tumor samples spanning 33 cancer types; used alongside STAR-Fusion and BREAKFAST with 5 kb and 100 kb minimum-distance cutoffs; contributed to the multi-tool ensemble producing 25,664 filtered fusions PMID:29617662

Notes

• Used in combination with STAR-Fusion and BREAKFAST; calls supported by multiple tools have greater confidence.
• Applied with minimum inter-gene distance cutoffs (5 kb and 100 kb) to reduce readthrough/artifact calls.

Sources

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