Immunoediting quantification

Overview

Computational scoring of genetic immunoediting based on the ratio of observed to expected neoantigens in a tumor; values below 1 indicate negative selection of neoantigen-bearing clones PMID:37202560.

Used by

• PMID:37202560 — applied in the AC-ICAM colon cancer atlas; quantifying genetic immunoediting (fewer observed neoantigens than expected) refined the prognostic value of the ICR signature PMID:37202560.

Notes

• Immunoediting quantification depends on neoantigen prediction pipelines, which carry known noise PMID:37202560.

Sources

• PMID:37202560

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