MutComFocal
Overview
MutComFocal is a computational tool developed to identify and prioritize genomic regions harboring both focal copy-number alterations and somatic point mutations within a cancer cohort. By integrating mutation frequency data with focal CNA calls (e.g., from GISTIC), it highlights candidate driver genes that are recurrently altered at both the sequence and copy-number level, providing a complementary signal to single-platform significance tests. The method helps focus attention on genomic loci under convergent selective pressure across multiple alteration classes.
Used by
- Used as part of the integrated multi-platform genomic analysis of 1,122 TCGA diffuse gliomas to identify candidate driver loci supported by co-occurring focal CNA and somatic mutation evidence across the cohort PMID:26824661
Notes
- Designed as a complement to GISTIC (focal CNA significance) and MutSig (mutation significance); integrates both signals to flag high-confidence driver candidates.
- Particularly useful in heterogeneous cohorts where single-platform significance thresholds may be under-powered.
- Developed in the context of TCGA pan-cancer analyses.
Sources
This page was processed by entity-page-writer on 2026-05-14.