SomaticSniper

Overview

SomaticSniper is a somatic SNV caller for paired tumor/normal sequencing. It identifies single nucleotide positions with different genotypes between tumor and normal samples using a Bayesian model. In the TCGA MC3 benchmark, SomaticSniper made the fewest overall calls among the seven callers but showed the lowest false-positive rate.

Used by

• One of seven somatic callers in the TCGA MC3 ensemble pipeline run on DNAnexus cloud across ~10,510 TCGA tumor/normal pairs; made the fewest calls overall but showed the lowest false-positive rate among all callers; run on DNAnexus cloud platform PMID:29596782

Notes

• Lowest false-positive rate but at the cost of sensitivity relative to other callers.
• Best suited for applications where specificity is paramount (e.g., driver-gene discovery).
• Non-default parameters were required for optimal performance in the MC3 context.

Sources

This page was processed by entity-page-writer on 2026-05-15.