Teratoma Assay

Overview

In vivo pluripotency assay in which human embryonic stem cells (heSCs) are injected into immunocompromised mice to form teratomas containing derivatives of all three germ layers; used to confirm pluripotency and as a source of tissue-specific progenitor cells.

Used by

• Used to generate experimental teratomas from the ES4 heSC line in immunocompromised mice; heMSCs (human embryonic mesenchymal stem cells) were subsequently isolated from teratoma-derived mesenchymal tissue and used as the cell-of-origin model for Ewing sarcoma. PMID:25186949

Notes

• Teratoma-derived heMSCs displayed CD73+/CD105+/CD90+/HLA-I+ surface markers, trilineage differentiation competence, and mitochondrial features consistent with an early developmental stage.

Sources

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