Colorectal Adenocarcinoma (COADREAD)

Overview

OncoTree parent for colon adenocarcinoma (COAD) and rectal adenocarcinoma. No paper in the current corpus targets COADREAD directly; this stub exists so child pages can resolve their parent: link.

Cohorts in the corpus

Recurrent alterations

  • Included in pan-cancer MSK-IMPACT pathway and metastasis analyses; RB1 oncogenic alterations enriched in brain and liver metastases in the pan-cancer cohort PMID:39506116.
  • Heterogeneous acquired resistance to combined KRASG12C + EGFR inhibition in KRASG12C-mutant colorectal cancer involves KRASG12C amplification (>20 copies) as a recurrent mechanism correlating with tumor markers and oncogene-induced senescence, with emergent alterations spanning RAS mutations (58.3%), RTK activation (75%), and MAPK pathway changes (58.3%) across 12 patients PMID:36355783
  • FBXO7 shallow deletions (heterozygous copy number loss) occur in 32.5% (169/526) of colorectal cancers (TCGA Pan-Cancer Atlas, n=526), associate with increased chromosome instability (aneuploidy score, tumor break load; q<0.0001), and correlate with significantly worse overall, progression-free, and disease-specific survival; CHEK1 inhibition via Prexasertib shows synthetic lethality in FBXO7-deficient colonic cells (EC50 5.83 nM vs 9.03 nM in controls) PMID:36334560
  • WES and WGS of 276 colorectal carcinomas (TCGA) identified 24 significantly mutated genes including APC (81%), TP53 (60%), KRAS (43%), PIK3CA (18%), ARID1A, SOX9, and AMER1; 16% of tumors were hypermutated; ERBB2 amplification (4%) identified as potentially targetable with trastuzumab PMID:22810696
  • 74-tumor WES cohort (Genentech) characterised colorectal adenocarcinoma genomic landscape; RSPO2/RSPO3 fusions mutually exclusive with APC loss establish Wnt pathway as universal driver PMID:22895193
  • Targeted NGS (MSK-IMPACT, 230 genes) of 69 matched primary/metastasis/normal trios from microsatellite-stable colorectal cancer showed 100% concordance for KRAS, NRAS, and BRAF mutations and 93% overall concordance for recurrent driver alterations between primary and metastatic sites. PMID:25164765
  • WES of 619 CRC tumour/normal pairs from NHS and HPFS cohorts (coadread_dfci_2016) identified 90 significantly mutated genes (73 novel); neoantigen load correlated with TILs (Spearman rho=0.36, p=2e-19) and improved CRC-specific survival (multivariate HR=0.57, p=0.03); HLA class I somatic mutations in 11% of cases were enriched in TIL-rich tumours, implicating antigen-presentation escape PMID:27149842
  • Prospective MSK-IMPACT sequencing of 1,134 colorectal adenocarcinomas (979 metastatic + 120 early-stage patients) identified 47 recurrently mutated genes; WNT pathway alteration reached 96% when intronic APC and large CTNNB1 exon-3 deletions were included; right-sided MSS mCRC had shorter OS (5-year 45% vs 67%, p<0.001) and distinct oncogenic enrichment versus left-sided PMID:29316426

Therapeutic landscape

  • NLP-augmented integrated survival-prediction models outperformed stage- or genomics-only models in colorectal cancer PMID:39506116.

Children

  • COAD — Colon Adenocarcinoma

Sources

This page was processed by crosslinker on 2026-05-06. - PMID:22810696

This page was processed by wiki-cli on 2026-05-06. - PMID:22895193

This page was processed by wiki-cli on 2026-05-06. - PMID:25164765

This page was processed by wiki-cli on 2026-05-11. - PMID:27149842

This page was processed by entity-page-writer on 2026-05-15. - PMID:29316426

This page was processed by entity-page-writer on 2026-05-15.