Colorectal Adenocarcinoma (TCGA, Firehose Legacy)

Overview

TCGA colorectal adenocarcinoma cohort (GDAC Firehose legacy release), used as an external comparator in the cbio-kb corpus PMID:37202560.

Composition

Assays / panels (linked)

  • TCGA multi-platform profiling (WES, RNA-seq, copy-number, methylation) as released through GDAC Firehose.

Papers using this cohort

  • PMID:37202560 — Roelands et al. used TCGA-COAD as a comparator to the AC-ICAM (coad_silu_2022) cohort; they noted TCGA-COAD’s limited survival follow-up and tumor-purity selection criteria as motivation for building the new fresh-frozen multi-omics resource PMID:37202560.

Notable findings derived from this cohort

  • Used as a reference cohort for benchmarking AC-ICAM’s ICR-based immune classification and for microbiome signature context PMID:37202560.

Sources

  • cBioPortal study coadread_tcga (TCGA Firehose Legacy).
  • Cancer Genome Atlas Network. Comprehensive molecular characterization of human colon and rectal cancer. Nature. 2012. PMID:22810696 — primary TCGA COAD/READ cohort paper (not in the cbio-kb corpus).

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