Small Bowel Well-Differentiated Neuroendocrine Tumor (SBWDNET)
Overview
Small Bowel Well-Differentiated Neuroendocrine Tumor (SBWDNET) is a well-differentiated neuroendocrine tumor arising from the small intestine, grouped under Gastrointestinal Neuroendocrine Tumor (GINET) in OncoTree. Small intestinal NETs (SI-NETs) are often somatostatin-receptor-positive and managed with somatostatin analogs.
Cohorts in the corpus
- pog570_bcgsc_2020 — small intestinal NET patient(s) within 28-patient metastatic NEN WGTA cohort at BC Cancer POG. PMID:24326773
Recurrent alterations
- Small-intestinal NETs in the POG cohort predominantly clustered in transcriptome Cluster A (with MEN1-mutant PanNETs and DAXX/ATRX-mutant cases). Whole-genome and transcriptome analysis identified actionable alterations; somatostatin analog therapy supported by high SSTR expression. Median TMB 2.19 mut/Mb across the 28-patient NEN cohort. PMID:24326773
Subtypes
- Well-differentiated (G1/G2) histology; high-grade SI-NETs are rare.
Therapeutic landscape
- Somatostatin analogs (octreotide, lanreotide) supported by high SSTR1/2/3/4/5 expression in SI-NET cases within the POG cohort. PMID:24326773
Sources
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