T-Lymphoblastic Leukemia/Lymphoma (TLL)
Overview
T-Lymphoblastic Leukemia/Lymphoma (OncoTree: TLL) is an aggressive lymphoid neoplasm of T-cell precursors. It appears in the corpus as part of the pediatric ALL cohort profiled alongside infant MLL-rearranged B-ALL PMID:25730765.
Cohorts in the corpus
- all_stjude_2015: Pediatric Cancer Genome Project cohort that included TLL samples in its broader ALL landscape analysis PMID:25730765.
Recurrent alterations
- Not specifically enumerated for TLL in this corpus; the focal analysis centered on MLL-rearranged B-ALL PMID:25730765.
- PIPseq cohort included T-lymphoblastic lymphoma cases; PMS2 homozygous S459X identified as diagnostic of constitutional mismatch-repair deficiency syndrome in one T-cell lymphoblastic lymphoma patient with consanguineous parentage PMID:28007021
- Germline WES of 372 pediatric cancer patients (Düsseldorf) included T-cell lymphoblastic leukemia/lymphoma cases; patient LPP_27 with T-cell ALL carried STK11 pLoF LP/PV c.179dup p.(Tyr60*) and congenital Peutz-Jeghers syndrome; patient LPP_07 (de novo TP53 c.586C>T) had T-cell ALL with lineage switch to BCP-ALL PMID:29489754
Subtypes
- Not characterized in this corpus.
Therapeutic landscape
- Not reported in this corpus.
Sources
This page was processed by entity-page-writer on 2026-04-08. - PMID:28007021
This page was processed by wiki-cli on 2026-05-14. - PMID:29489754
This page was processed by wiki-cli on 2026-05-15.