Acute Lymphoblastic Leukemia (St Jude, Nat Genet 2015)

Overview

This dataset, generated as part of the Pediatric Cancer Genome Project (PCGP), provides a comprehensive mutational landscape of infant acute lymphoblastic leukemia (ALL) with MLL (KMT2A) rearrangements.

Composition

  • Cancer Types: BLLKMT2A (Infant MLL-R ALL) and TLL.
  • Cohort Size: 65 infants (47 MLL-R and 18 non-MLL-R) and 20 older children (MLL-R).

Assays / panels (linked)

Papers using this cohort

  • PMID:25730765: The primary study defining the mutational landscape of infant MLL-rearranged ALL.

Notable findings derived from this cohort

  • Infant MLL-R ALL has one of the lowest somatic mutation frequencies in human cancer, averaging only 1.3 non-silent mutations per case PMID:25730765.
  • Activating mutations in kinase/PI3K/RAS signaling pathways are found in 47% of infant MLL-R cases, but are frequently sub-clonal and lost at relapse PMID:25730765.

Sources

This page was processed by crosslinker on 2026-04-08.