JTE-013

Overview

JTE-013 is a selective antagonist of sphingosine-1-phosphate receptor 2 (S1PR2). In cholangiocarcinoma (CHOL), S1PR2 is activated by taurocholic acid, triggering ERK/AKT/NF-kB cascades and upregulating PTGS2 (COX-2), which suppresses CD8+ T-cell activity and recruits regulatory T cells. JTE-013 blocks these pro-tumorigenic and immunosuppressive downstream effects.

Evidence in the corpus

• JTE-013 (S1PR2 antagonist) suppresses tumor invasiveness in preclinical CCA models by blocking taurocholic-acid–activated S1PR2→ERK/AKT/NF-kB→PTGS2 (COX-2) signaling that drives CD8+ T-cell suppression and regulatory T-cell recruitment PMID:25608663

Resistance mechanisms

Cancer types (linked)

• CHOL — cholangiocarcinoma

Sources

• PMID:25608663

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